Found inside – Page iiThis book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the ... 2021 Jun 8. doi: 10.1007/s12017-021-08669-9. He is co-founder and Chief Scientific Officer of Cleveland BioLabs, Inc and Tartis, Inc. His area of general research interest includes drug discovery, gene discovery, molecular targets for cancer treatment. Alejandro Torres-Hernandez et al. The cGAS-STING pathway is responsible for the tumor response of antigen-presenting cells, leading to type I IFN secretion and T cell activation, inducing tumor recession. Bookshelf eCollection 2021. Current Opinion in Immunology; View 2 excerpts, cites background; Save. His laboratory identified the first human Smad gene, SMAD4, as well as the first cancer mutations in Smad4, BRCA2, and other genes. An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the ... Editorial Boards: To investigate this finding further, we next examined STING expression across a panel of KL versus KP lung cancer cell lines. Activation of the STING pathway is a central innate immune sensing mechanism that leads to type I IFN production in the tumor microenvironment. Clowes Memorial Award, 2003, Brian J. Druker, MD, PhD, member of the National Academy of Sciences, Professor, Oregon Health & Science University, Director, OHSU Knight Cancer Institute, Oregon Health & Science University. 101) Ma, Z and Damania, B. Found insideThe papers presented in this volume were invited from experts in diverse areas of tumor immunology and closely related subjects. Jiri Bartek has a total of more than 320 publications in peer reviewed journals (about 30-40 in Nature, Science and Cell), with over 26.000 citations. Autophagy, Gao Y, Qin Y, Wan C, Sun Y, Meng J, Huang J, Hu Y, Jin H, Yang K. Front Oncol. Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation. Moreover, cGAS detects tumor-derived DNA and stimulates endogenous antitumor immunity. 6(8): 2361 . He has served as Associate Editor of Neuromolecular Med. Tanaka M, Dykes SS, Siemann DW (CTHR). Harold L. Moses, PhD, Professor, Vanderbilt-Ingram Cancer Center, Nashville, TN. Authoritative and easily accessible, Human Cytomegaloviruses: Methods and Protocols serves as a tool for basic scientists as well as clinical scientists with an interest in the basic fundamental aspects of viral gene expression and specific ... George C. Reisman Professor of Medicine and Professor of Pathology, Medicine, Harvard Medical School . Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key node to be targeted in a synthetic lethal approach. Director, Cancer Research Institute, Beth Israel Deaconess Medical Center, Nickolas Papadopoulos, Ph.D. Ludwig Professor of Cancer Research at The Johns Hopkins University School of Medicine, and the associate director for research at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Dr. Vogt is an elected member of many prestigious academies, including the American Academy of Arts and Sciences, the National Academy of Sciences, the Institute of Medicine of the National Academies, and the American Academy of Microbiology. PRMT5 methylation of IFI204 determines the degree of cGAS/STING pathway activation. 2021 Mar 8;56(5):627-640.e5. Twitter – https://twitter.com/oncotarget Oncotarget. These works have ushered and have changed some central paradigms that have strengthened the importance of context in the development of cancer. Epub 2018 Nov 16. Introduction There exists a relationship between a tumor and the immune system, and the latter selectively recognizes and kills tumor cells through immune surveillance.1 Consequently, tumor cells have evolved mechanisms to bypass this process, hijacking the immune system to promote tumor formation.2,3 Therefore, the dual regulation of the immune system […] Found insideThis book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Alexander Varshavsky is a recipient of the Albert Lasker Award for Basic Medical Research, the Wolf Prize in Medicine and the Louisa Gross Horwitz Prize from Columbia University in 2001 for his research on ubiquitination. 2016 Jul 19;7(29):45144-45157. Dr. Nakamura received the Keio Medical Science Prize and the Tomizo Yoshida Award of the Japanese Cancer Association. Figure 2. In 2006 he won the March of Dimes Prize in Developmental Biology and he won the 2007 $1 million Gotham Prize for an original approach to killing cancer cells. Dr. Blazar is the Director of the University of Minnesota's Clinical and Translational Science Institute. 2016 Jul 19;7(29):45144-45157. Innate immunity is triggered by the escape of nuclear or mitochondrial dsDNA into the cytosol. He has published over 350 papers on his work in the fields of cell cycle, gene therapy and the genetics of cancer. 8600 Rockville Pike Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling. Found inside – Page iAdvances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. 2020 Jul 28 . ( A-C ) B16 cells were: transduced with either scramble (Scr) or Prmt5-specific shRNAs (shPRMT5-1, shPRMT5-2) (A), treated for 24 hr with PRMT5i (EPZ015666, 10 μM) (B), or subjected to ectopic expression of control (pLX304 and pLenti) or PRMT5 + WDR77 . Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application. This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. Dr.Bertino has received several awards and honors, including the Rosenthal Award from the American Association of Clinical Research, the Karnofsky Award from the American Society for Clinical Oncology, and the American Cancer Society Medal of Honor. Sign up for free Altmetric alerts about this article, DOI - https://doi.org/10.18632/oncotarget.27673, Full text - https://www.oncotarget.com/article/27673/text/, Correspondence to - Brandon Yi Da Hoong - brandon.hoong@u.nus.edu and Ee Sin Chen - bchces@nus.edu.sg, Keywords - Kenneth Cowan, M.D., Ph.D., Professor, University of Nebraska Medical Center, Omaha, NE, Director, Eppley Institute, Director, UNMC Eppley Cancer Center. Because the mitochondrial inner membrane is thought to remain intact during apoptosis, we sought to address how matrix mtDNA could activate the cytosolic cGAS‐STING signalling pathway. While there is great potential for using cGAS-STING agonists as anti-cancer agents, their use as clinical therapeutics should proceed cautiously due to the risk of tumorigenesis associated with chronic cGAS-STING activation and non-canonical downstream signaling. (2020). Dr. Karin also serves on several advisory boards and was cofounder of Signal Pharmaceuticals (currently Celgene). cGAS-STING pathway in oncogenesis and cancer therapeutics. The Stimulator of Interferon Genes (STING) pathway is implicated in the innate immune response and is important in both oncogenesis and cancer treatment. However, use of STING agonists (STINGa) as a . NCI CPTC Antibody Characterization Program, Yang H, Wang H, Ren J, Chen Q, Chen ZJ. In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He was appointed as a professor at the Institute of Medical Science, University of Tokyo in 1994 and the Department of Medicine at the University of Chicago in 2012. Burkholderia pseudomallei is a bacterial pathogen that causes melioidosis, an infectious disease in the tropics with high morbidity and mortality. This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in ... She received postdoctoral training and eventually served as Senior Staff Investigator at Cold Spring Harbor Laboratory in Long Island. 11, No. He is currently member of the editorial boards of 10 high-medium impact biomedical journals and has won a number of awards including: (1991,1992) Czech Medical Association Award, (2000) Elected EMBO member, (2002) A. Benzon Prize, (2003) Novo Nordisk Prize, (2003) G.J. This includes the number of novel mechanisms that has never before been discussed in previous monographs. Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. Specifically, activation of the cytosolic DNA sensor STING in antigen-presenting cells (APCs) induces a type I interferon response and cytokine production that facilitates antitumor immune therapy. Thus, the cGAS-STING pathway is a promising target for cancer immunotherapy. -, Shen YJ, Le Bert N, Chitre AA, Koo CX, Nga XH, Ho SS, Khatoo M, Tan NY, Ishii KJ, Gasser S. Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells. cGAS/STING is required to mediate the antitumour effects of LGG and combination treatment with anti-PD-1 antibody. Twitter - https://twitter.com/oncotarget However, it is also clear that some tumors evade cGAS-STING-mediated . The development of new therapeutics to treat v. This volume provides a broad spectrum of research models, techniques, and protocols. In 1995, she joined the faculty of the Department of Molecular Genetics and Microbiology at SUNY and served as Department Chair from 2003-2006. cGAS-STING pathway in oncogenesis and cancer therapeutics Oncotarget. Int J Cancer, PubMed PMID: 34101090; PubMed Central PMCID: PMC8186014. ; Chen, E.S. There seems to exist a delicate equilibrium between the virus and host response to infection. Depletion of STING in human and murine cancer cells and tumors resulted in increased . EMBO Rep. 2018 Dec;19(12):e46935. Chief, Division of Genetics, Dept of Medicine, Beth Israel Deaconess Medical Center This paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National Cancer Institute in the summer of 2017. Dr. Stephen B. Baylin is professor of oncology and medicine, director of the cancer biology program at the oncology center, and the Virginia and D.K. Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, Bowman TV. From January 1, 2021 Oncotarget is a biweekly journal that is published on Tuesday. Impact Journals is a member of the Society for Scholarly Publishing. Learn how your comment data is processed. cGAS-STING pathway in oncogenesis and cancer therapeutics 28 July 2020 | Oncotarget, Vol. 2016. Bert Vogelstein, M.D., member of the National Academy of Sciences, Professor, Johns Hopkins University, Baltimore, MD. Molecular Cancer Therapeutics. Levine is a member of the National Academy of Sciences and of the Academy's Institute of Medicine; [Epub ahead of print] Review. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. 2017; 114:E4612–E4620. Coordination of innate and adaptive immune signaling resulting from cGAS-STING activation. Role of the cGAS-STING pathway in cancer development and oncotherapeutic approaches. International Immunology; Dr. Baylin has been a member of committees of the American Cancer Society and the National Institutes of Health, and his multiple honors include a Research Career Development Award from the National Institutes of Health. Defining the immune profile of tumors and elucidating the pathways controlling the anti- and pro-tumor effects of cGAS-STING activation will pave the way forward for its implementation in anti-cancer therapy. [email protected] Peter K. Vogt, Ph.D, member of the National Academy of Sciences Professor, The Scripps Research Institute, La Jolla, CA. Coordination of innate and adaptive…. Recent studies reveal critical roles for this pathway in natural antitumor immunity across cancer types as well as in immune checkpoint blockade therapy. This book examines this quasi-evolutionary process involved and how work in both molecular and computational biology is shedding light on it. Here the Oncotarget authors discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs. Bert Vogelstein is a Howard Hughes Medical Institute investigator. After earning her undergraduate and master's degree in Biochemistry from Bar-Ilan University in Israel, Dr. Bar-Sagi completed a PhD in Cell Biology at the State University of New York, Stony Brook (SUNY). Found insideIn Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets ... Oncotarget (a primarily oncology-focused, peer-reviewed, open access, biweekly journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Mechanism: PARK2 is a component of E3 ubiquitin ligase complexes that drive cyclin D and E degradation. Oncotarget: cGAS-STING pathway in oncogenesis and cancer therapeutics. Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas, Oncotarget: Replication-stress sensitivity in breast cancer cells, Comprehensive clinical sequencing opens door to the promise of precision medicine, Oncotarget: Fgr and Numb in retinoic differentiation and G0 arrest of non-APL AML cells, Short chain fatty acids: An ‘ace in the hole’ against SARS-CoV-2 infection, Radio waves remotely triggered the release of insulin in mice, USC study shows dire impacts downstream of Nile River dam, Long COVID symptoms likely caused by Epstein-Barr virus reactivation, Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy, Improving air quality reduces dementia risk, multiple studies suggest, Elsevier partners with American College of Medical Genetics and Genomics to publish Genetics in Medicine, Juicy past of favorite Okinawan fruit revealed. Nature. Oncotarget: cGAS-STING pathway in oncogenesis and cancer therapeutics. Disclaimer, National Library of Medicine Perturbation of the cGAS-STING pathway in HSPCs may be involved in the pathogenesis of hematopoietic disorders, autoimmune diseases . Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topi Ferroptosis is a more recently recognized form of cell death that relies on iron-mediated oxidative damage. Reddit – https://www.reddit.com/user/Oncotarget/, Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls, Media Contact Accessibility Signal transduction coordinated by the…. Molecular Medicine (Contributing editor; 1997-present); Paul Workman, The Institute of Cancer Research, London, UK. Cell Host Microbe. STING, Nature. LinkedIn - https://www.linkedin.com/company/oncotarget Dr. Bertino is the author and co-author of more than 400 scientific publications. MEDIA@IMPACTJOURNALS.COM Your email address will not be published. stimulator of interferon, he is also the author or coauthor of over 300 scientific papers, as well as a book, Viruses (1993). 2021 Feb 23;12(3):328-330. doi: 10.1021/acsmedchemlett.1c00085. Koenraad Van Doorslaer, PhD. She relocated to New York University Medical Center in 2006, where she is currently Professor and Chair of the Department of Biochemistry. cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. Hoong BYD, Gan YH, Liu H, and Chen ES. Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. Recent studies reveal critical roles for this pathway in natural antitumor immunity across cancer types as well as in immune checkpoint blockade therapy. A deeper mechanistic understanding of the cGAS-STING pathway will aid in the identification of potentially efficacious anti-cancer therapeutic targets. He was elected as a member of the Chinese Academy of Sciences in 2005. cGAS-STING pathway in oncogenesis and cancer therapeutics 28 July 2020 | Oncotarget, Vol. Featured articles by DR Lowy, the acting director of the NCI (2015-2017), and A. Levine: Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. Redox Paradox: A novel approach to therapeutics-resistant cancer. Please enable it to take advantage of the complete set of features! Mendel Medal, (2006) Danish Cancer Society Prize, Stephen B. Baylin, M.D., Professor, Deputy Director, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Virginia and DK Ludwig Professor of Oncology, Baltimore, MD, USA. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate immune response initiator. He has been an American Cancer Society professor since 1976. Current interests include pharmacogenomics, mitotic instability, and the clinical significance of cancer biomarkers. Dynamic changes during the treatment of pancreatic cancer. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. Advances in Immunology; MeSH cGAS-STING. 2019), presumably due to the mitotic defects or increased replication stress caused by PARPi affecting replication fork speed (Maya-Mendoza et al . cGAS-STING pathway in oncogenesis and cancer therapeutics. p62-mediated selective autophagy inhibits cGAS-STING signaling through different mechanisms. Mikhail V. Blagosklonny, M.D., Ph.D., Professor, Roswell Park Comprehensive Cancer Center, Buffalo, NY. Unable to load your collection due to an error, Unable to load your delegates due to an error. Developing anticancer therapeutics by enhancing STING signaling in tumors thus may generate clinical benefit by impacting both cancer cells and the tumor microenvironment. Dr. Bertino has been internationally recognized for his role in finding curative treatments for leukemia and lymphoma. Oncotarget Volume 11, Issue 30 reported that recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. eCollection 2021 Mar 11. Alexander Varshavsky, Ph.D, member of the National Academy of Sciences, Professor, California Institute of Technology, Pasadena, CA. Redox Signal. Wang D, Qian X, Rajaram M, Durkin ME, Lowy DR. cyclic GMP-AMP synthase, In 2008, she was appointed Chair of the Scientific Advisory Board of the Pancreatic Cancer Action Network. Mitochondrial dynamics (fission and fusion) can also sustain cancer cell migration, tumor growth and oncogenic transformation. He is a member of the Association of American Physicians. He is the recipient of He is the recipient of the 2003 Excellence in Mentoring Award from the American Association of Immunologists and the 2004 Clowes Memorial Award from the American Association of Cancer Research. Found inside – Page iCutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now ... The cytosolic DNA taken up by APCs can be recognized by the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS) and activate the STING pathway . cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. -, MacKenzie KJ, Carroll P, Martin CA, Murina O, Fluteau A, Simpson DJ, Olova N, Sutcliffe H, Rainger JK, Leitch A, Osborn RT, Wheeler AP, Nowotny M, et al.. cGAS surveillance of micronuclei links genome instability to innate immunity. We have been honored to have Dr. Pardee as a Founding Editor of Oncotarget. Specifically, activation of the cytosolic DNA sensor STING in antigen-presenting cells (APCs) induces a type I interferon response and cytokine production that facilitates antitumor immune . Specialized RNA- and DNA-sensing receptors police subcellular compartments for infiltrating foreign nucleic acids, and, upon recognition, trigger immune signaling pathways that initiate a host defense. Hoong BYD, Gan YH, Liu H, and Chen ES. However, use of STING agonists (STINGa) as a . STING; cGAS; cyclic GMP-AMP synthase; interferon; stimulator of interferon. Oncotarget Volume 11, Issue 30 reported that recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. However, recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. However, the mechanisms of MDV-induced immunosuppression and tumorigenesis remain largely unknown. A deeper mechanistic understanding of the cGAS-STING pathway will aid in the identification of potentially efficacious anti-cancer therapeutic targets. Publications . PLOS ONE and as Editor-in-Chief of Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy. Dr. Yusuke Nakamura discovered the APC (Familial Adenomatous Polyposis) tumor suppressor. In this White Paper, we discuss the current state of microbial cancer therapy. Dr. Bar-Sagi has published over 100 peer-reviewed articles in leading scientific journals. Because checkpoint blockade is most effective in patients with inflamed or "hot" tumors, a priority . PLoS Pathog. the Breakthrough Prize, the highest prize ever, https://doi.org/10.18632/oncotarget.27673, https://www.oncotarget.com/article/27673/text/, https://www.linkedin.com/company/oncotarget. He received his M.D. 2016 Feb 11;12(2):e1005326. cyclic GMP-AMP synthase, However, it is also clear that some tumors evade cGAS-STING-mediated . show that disruption of the catalytic subunit of DNA polymerase ζ, Rev3l, results in the accumulation of DNA damage and increased expression of interferon-stimulated genes. Here we discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs. It is with sadness that we share the passing of our Editorial Board Member, Arthur Pardee, who died February 24, 2019 at the age of 97. Figure 1. Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key node to be targeted in a synthetic lethal approach. Fox Chase Cancer Center, Philadelphia, PA, Michael A. Dyer, PhD, Professor/Member, St. Jude Faculty Co-Leader, Developmental Therapeutics for Solid Malignancies Program, Andrew Feinberg, MD, MPH, King Fahd Professor of Molecular Medicine Department of Medicine, Department of Oncology and Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine, Dean W. Felsher, MD, PhD, Stanford University School of Medicine, Stanford, CA, Antonio Giordano, MD, Ph.D, Professor and Director, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA. The Stimulator of Interferon Genes (STING) pathway is implicated in the innate immune response and is important in both oncogenesis and cancer treatment. Given the critical role of the cGAS-STING pathway in cancer immunity, there has been intense research effort to develop STING agonists for cancer immunotherapy. A deeper mechanistic understanding of the cGAS-STING pathway will aid in the identification of potentially efficacious anti-cancer therapeutic targets. He was also elected an Honorary Member of the Japanese Cancer Association and received an honorary doctorate from the University of Würzburg. Professor of Medical Oncology Martin et al. (1973); Hirschl Award (1983); Searle Scholar; (1983) Mallinckrodt Scholar; (1984); NIH Merit Award (1991); National Academy of Sciences (1994); American Academy of Microbiology (1994); American Academy of Arts and Sciences (1994); Associate (Foreign) Member, European Molecular Biology Organization (1999); Excellence in Mentoring Award,Association of Immunologists (2003); American Association of Cancer Research B.H.A. Stage-specific protein-domain mutational profile of invasive ductal breast cancer: Yu, T.; Choi, K.P. In turn, the cGAS-STING pathway promotes p62-mediated selective autophagy. Immunotherapies such as checkpoint blockade have achieved durable benefits for patients with advanced stage cancer and have changed treatment paradigms. Dr. Karin has received numerous awards including the Oppenheimer Award for Excellence in Research from the Endocrine Society, The Herman Beerman Lectureship from the Society of Investigative Dermatology, C.E.R.I.E.S. He was the founding editor of the Journal of Clinical Oncology. The intrinsic function of cGAS-STING facilitates type-I interferon (IFN) and other inflammatory signaling responses. Cancer Biol Ther, 2017; 548:461–465. Oncotarget 11, 2930-2955. Nat Cell Biol. The cGAS-STING pathway protects cells against a variety of pathogens and cancer by enhancing anti-tumor immune responses (Barber, 2015), while aberrant activation of the STING by self-DNA is associated with autoimmune diseases (Ahn et al., 2012). Pinterest - https://www.pinterest.com/oncotarget/ Chromosomal instability (CIN) in cancer cells has been reported to activate the cGAS-STING innate immunity pathway via micronuclei formation, thus affecting tumor immunity and tumor progression . Feb 10; 150-158. Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject. The cGAS-STING pathway modulates cellular processes such as autophagy, cell survival, senescence and interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease and cancer. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. 27 European & South American Universities: M.D.H.C., D.H.C., D.Sc.H.C., D.Nat. Notify me of follow-up comments by email. Defining the immune profile of tumors and elucidating the pathways controlling the anti- and pro-tumor effects of cGAS-STING activation will pave the way forward for its implementation in anti-cancer therapy. Targeting Stimulator of Interferon Genes (STING) for the Potential Treatment of Cancer and Infectious Diseases. Moreover, cGAS detects tumor-derived DNA and stimulates endogenous antitumor immunity. A Virological Perspective on Cancer. Sc. Associate Professor, Department of Oncology, Director of Translational Genetics, Ludwig Center for Cancer Genetics & Therapeutics, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Institutions, CRB1, Room 585, 1650 Orleans Street, Baltimore, MD 21231, Arthur B. Pardee, Ph.D, member of the National Academy of Sciences, Professor of Biological Chemistry and Molecular Pharmacology Emeritus, Harvard Medical School. Wolff RA et al. President & CEO of Roswell Park Comprehensive Cancer Center, the Wallace Family Chair in Translational Research, and Professor of Oncology. Epub 2018 Nov 20. FOIA 10.1073/pnas.1705499114. The cGAS-STING Pathway: Novel Perspectives in Liver Diseases. By Dr. Surat P, Ph.D. This is a print on demand edition of a hard to find publication. In 2009 he won the Lasker Clinical Award and the Meyenburg Cancer Research Prize for his influential work in the development of STI571, commonly known as Gleevec, for the treatment of Chronic Myeloid Leukemia. eCollection 2021. This book is the first current, comprehensive review of its kind in the market. The DNA tumor viruses are central to many branches of molecular and cellular biology. Facebook – https://www.facebook.com/Oncotarget/ found that SYK is an attractive target for experimental therapeutics in treating hepatic fibrosis and oncogenesis. We seek to understand how cancer-instrinsic genomic instability engages the cGAS-STING pathway, to identify factors that antagonize the cGAS-STING response to genomic instability, and to determine if cGAS-STING activation can serve as a predictive biomarker for the success of immune checkpoint blockade in the treatment of non-small cell lung . Biology is shedding light on it in the identification of potentially efficacious anti-cancer targets! In this volume were invited from experts in diverse areas of tumor Immunology and closely related.... Treatment of cancer Maya-Mendoza et al tumors, a priority ) for the treatment. 56 ( 5 ):627-640.e5 to rationalize the aging process common to all living beings the Breakthrough Prize, STING-cGAS... Dr. Blazar is the author and co-author of more than 400 scientific publications: e1005326 Professor since 1976 of in. 29 ):45144-45157 in 2006, where she is currently Professor and Chair of the University of.! 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Potentially efficacious anti-cancer therapeutic targets this critical field, anywhere from basic research to health organization!: M.D.H.C., D.H.C., D.Sc.H.C., D.Nat because checkpoint blockade is cgas-sting pathway in oncogenesis and cancer therapeutics effective in with...
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